The effect of rifampicin on piroxicam kinetics.
نویسندگان
چکیده
Rifampicin is known to influence the metabolic disposition of other drugs because of its 'enzyme inducing' effects in the liver (1, 6). The microsomal enzymes catalyze glucuronide conjugations and most of the oxidation of the drugs. Reduction and hydrolysis of drugs are catalyzed by both microsomal and non-microsomal enzymes (3). Hydroxylation and glucuronide formation are involved in the metabolic pathway of piroxicam, a non-steroidal anti-inflammatory drug (NSAID) (4). The metabolite is less active than piroxicam (». Hence we report here interaction study between rifampicin and piroxicaform.
منابع مشابه
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ورودعنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 32 3 شماره
صفحات -
تاریخ انتشار 1988